Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloral → (2R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloral | HCID 6407 | — |
| 반응물 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | (3R)-2-methyl-3-hydroxybutanoic acid | HCID 18633016 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (2R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one | HCID 57161429 | 83.5% |
반응 단계
A mixture of (3R)-2-methyl-3-hydroxybutanoic acid 3.6 g, chloral 8.3 g, pyridinium p-toluenesulfonate (PPTS) 0.7 g and dichloromethane 20 ml was refluxed for 25 hours under a dehydration condition. 40 ml of a saturated aqueous sodium hydrogen carbonate was added thereto and the resulting separated organic phase was dried over anhydrous magnesium sulfate and the solvent was distilled off to obtain 6.3 g of (2R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411877 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-1b232995cdb4485884eb9ac2fd24a0fa |
| 출처 메모 | uspto-grants-1995_05 |