Aniline → 4-Anilino-7-trifluoromethylquinazoline

HRID 358031

반응식

HRID 358031 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(O)C>[NH:16]([C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 6115AnilineHCID 128067424-Chloro-7-(trifluoromethyl)quinazoline

생성물 1

HCID 128067734-Anilino-7-trifluoromethylquinazoline수율 60%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.5 g of 4-chloro-7-trifluoromethylquinazoline were dissolved in 10 ml of ethanol, and 1.0 g of aniline was added to the solution. Reaction occurred violently and the reaction mixture solidified immediately. After cooling, the solidified product was collected and washed with ethanol. The resulting crystals were pulverized and added to a dilute aqueous solution of sodium hydroxide. Insolubles were filtered off and recrystallized from ethanol to give 1.7 g (yield 60%) of the desired Compound No. 17 in the form of colourless plates melting at 230°-232° C.

후처리

  1. customReaction
  2. temperatureAfter cooling
  3. customthe solidified product was collected
  4. washwashed with ethanol
  5. additionadded to a dilute aqueous solution of sodium hydroxide
  6. filtrationInsolubles were filtered off
  7. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-286f2e10af6c4eb48b67a76a2bfad034
출처 데이터셋
uspto-grants-1984_08
특허 번호
US04464375

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