Ethanol → N,N'-Dicyclohexylurea

HRID 358109노트

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HRID 358109 반응식
C(CC(OC1C=[C:10]([C:14]2[N:15]=[C:16]3[N:20]([CH:21]=2)[C:19]2[CH:22]=[CH:23][CH:24]=[CH:25][C:18]=2S3)[CH:11]=[CH:12][CH:13]=1)=O)(O)=O.C([OH:28])C.C1(N=C=NC2CCCCC2)CCCCC1>O1CCCC1>[CH:19]1([NH:20][C:16]([NH:15][CH:14]2[CH2:10][CH2:11][CH2:12][CH2:13][CH2:21]2)=[O:28])[CH2:18][CH2:25][CH2:24][CH2:23][CH2:22]1

참가 물질

5

반응물 3

HCID 702EthanolHCID 10868DicyclohexylcarbodiimideHCID 137307YM 13650

생성물 1

HCID 4277N,N'-Dicyclohexylurea

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a mixture of 4 g of 2-(m-carboxyacetoxyphenyl)imidazo[2,1-b]benzothiazole, 0.52 g of ethanol, and 50 ml of tetrahydrofuran was added a mixture of 2.3 g of dicyclohexylcarbodiimide and 10 ml of tetrahydrofuran at a temperature below 10° C. Thereafter, the mixture was stirred overnight at room temperature. Dicyclohexyl urea thus formed was filtered off and the filtrate was concentrated under reduced pressure. The residue was applied to silica gel column chromatography (80 ml of silica gel, eluate: a mixture of toluene and ethyl acetate (9:1)) to provide 2.0 g of oily 2-(m-ethoxycarbonylacetoxyphenyl)imidazo[2,1-b]benzothiazole.

후처리

  1. additionwas added

출처 및 근거

ORD 기록
ord-d527bffdb09447ec874148bbd199ad2e
출처 데이터셋
uspto-grants-1984_08
특허 번호
US04464384

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