Sulfuryl chloride → 2,4,6-Trichloropyrimidine-5-carbonyl chloride

반응식

[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([CH:9]=[O:10])=[C:4]([Cl:11])[N:3]=1.S(Cl)([Cl:15])(=O)=O>>[Cl:1][C:2]1[N:3]=[C:4]([Cl:11])[C:5]([C:9]([Cl:15])=[O:10])=[C:6]([Cl:8])[N:7]=1

참가 물질

반응물 2

HCID 24648Sulfuryl chloride

HCID 109327462,4,6-Trichloro-5-pyrimidinecarboxaldehyde

생성물 1

HCID 132643612,4,6-Trichloropyrimidine-5-carbonyl chloride

실험 절차

In a first step, 2,4,6-trichloro-pyrimidine-5-carbaldehyde (I) is reacted with sulfuryl chloride to form 2,4,6-trichloropyrimidine-5-carboxylic acid chloride (II). The acyl chloride (II) is reacted, by a Friedel-Crafts-reaction, with an appropriately substituted benzene to form a 2,4,6-trichloro-pyrimidine-5-yl-aryl-ketone (III). Compound III is reacted with an aromatic amine in the presence of a tertiary amine to form a 2,4-dichloro-5-aroyl-6-arylamino-pyrimidine (IV).

출처 및 근거

ORD 기록: ord-ab18ff4bc7e04237886fdcb6d9e1d6b4
출처 데이터셋: uspto-grants-1984_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04464457

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