Methanimidic acid, N-phenyl-, ethyl ester → HCID 178482101, 화합물

HRID 358258

반응식

HRID 358258 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:4][CH:3]=1.[C:13]1([N:19]=[CH:20]OCC)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CC(C)=O>[C:13]1([NH:19][CH:20]=[N:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[N:9]=[CH:10][NH:11][CH:12]=3)=[CH:6][CH:7]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 111236Methanimidic acid, N-phenyl-, ethyl esterHCID 178507418HCID 178507418, 화합물

생성물 1

HCID 178482101HCID 178482101, 화합물수율 56.9%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Five grams of 4-(4-aminophenyl)-1-H-imidazole were added to a solution of 4.6 gm of ethyl N-phenyl-formimidate [Org. Synth., 35, 65 (1965)] in 25 ml of acetone. After stirring for four hours at room temperature, the solid that separated was filtered and dried under vacuum. The product was treated with acetone and acidified with glacial acetic acid. N-Phenyl-N'-[4-(imidazol-4-yl]-formamidine crystallized as acetate salt which was filtered to give 4.6 gm of the desired product.

후처리

  1. customthe solid that separated
  2. filtrationwas filtered
  3. customdried under vacuum
  4. additionThe product was treated with acetone
  5. customN-Phenyl-N'-[4-(imidazol-4-yl]-formamidine crystallized as acetate salt which
  6. filtrationwas filtered

출처 및 근거

ORD 기록
ord-699e0aeb59e647b5813b7ec3e468f229
출처 데이터셋
uspto-grants-1984_08
특허 번호
US04465841

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