Dodecane, 1-isocyanato- → N-n-Dodecylaminocarbonyl-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline

HRID 358328

반응식

HRID 358328 반응식
[CH3:1][C:2]1([CH3:13])[CH2:11][CH:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.[CH2:14]([N:26]=[C:27]=[O:28])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>CCOCC>[CH2:14]([NH:26][C:27]([N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:10]([CH3:12])[CH2:11][C:2]1([CH3:13])[CH3:1])=[O:28])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

참가 물질

4

반응물 2

HCID 77873Dodecane, 1-isocyanato-HCID 107292Quinoline, 1,2,3,4-tetrahydro-2,2,4-trimethyl-

생성물 1

HCID 12901826N-n-Dodecylaminocarbonyl-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline수율 66%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
-70 °C

실험 절차

0.1 mole of 2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline is dissolved in 50 ml of ether and the solution is mixed with 0.1 mole of n-dodecyl isocyanate. A spatula tip of diazadicyclooctane is then added, the mixture is left to stand for 7 days at 20° to 25° C. and cooled at -70° C. and the precipitate which has separated out is filtered off. N-n-Dodecylaminocarbonyl-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline with a melting point of 48°-50° C. is obtained. Yield: 66% of theory.

후처리

  1. additionA spatula tip of diazadicyclooctane is then added
  2. waitthe mixture is left
  3. customthe precipitate which has separated out
  4. filtrationis filtered off

출처 및 근거

ORD 기록
ord-7a959d971acf4df9b13af608de9f97a4
출처 데이터셋
uspto-grants-1984_08
특허 번호
US04466964

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