Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → Quinazoline, 4-(2-(4-chlorophenyl)ethoxy)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | p-Chlorophenethylic alcohol | HCID 74647 | — |
| 반응물 | 4-Chloroquinazoline | HCID 78864 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Quinazoline, 4-(2-(4-chlorophenyl)ethoxy)- | HCID 164154 | 2.4% |
반응 단계
To a solution of 1.1 g of sodium hydride in 50 ml of DMF was added 3.4 g of 2-(4-chlorophenyl)ethanol, and the mixture was stirred at room temperature for one hour. Then 3.6 g of 4-chloroquinazoline in 20 ml of DMF were added, and the mixture was stirred overnight. The mixture was then poured into a mixture of ice in water. Solid was collected and recrystallized from pentane giving 0.149 g of the title product. Yield: 2.4%. M.P. 57°-58° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411963 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-ca27611c751f4bdab9cd7b26cf35749a |
| 출처 메모 | uspto-grants-1995_05 |