Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 8-Fluoro-4-[2-(4-methylphenyl)ethoxy]quinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4-Methylphenethyl alcohol | HCID 95294 | — |
| 반응물 | 4-Chloro-8-fluoroquinazoline | HCID 19939133 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 8-Fluoro-4-[2-(4-methylphenyl)ethoxy]quinazoline | HCID 19939085 | — |
반응 단계
To a mixture of 0.6 g of sodium hydride (50%, suspension in oil) and 2 g of 4-chloro-8-fluoroquinazoline in 20 ml of DMF was added 1.64 g of 2-(4-methylphenyl)ethanol, and the mixture was stirred for one hour. Then the mixture was poured into ice water. The solid was collected by filtration. Yield: 0.7 g (20.5%). M.P. 72°-74° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411963 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-25910daf5c584d5dabadded8b8a7a749 |
| 출처 메모 | uspto-grants-1995_05 |