Thionyl Chloride → 3-Fluoro-2-methylbenzoyl chloride

반응식

[F:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].S(Cl)([Cl:14])=O>>[F:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([Cl:14])=[O:6]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 2466823-Fluoro-2-methylbenzoic acid

생성물 1

HCID 27792403-Fluoro-2-methylbenzoyl chloride

실험 절차

A solution of 2.87 g of 3-fluoro-2-methylbenzoic acid in 25 ml of thionyl chloride is refluxed for 1.75 hour and the excess thionyl chloride removed under vacuum. To the residue is added toluene (several times) and the toluene removed under vacuum after each addition to give 3-fluoro-2-methylbenzoyl chloride.

후처리

customthe excess thionyl chloride removed under vacuum
additionTo the residue is added toluene (several times)
customthe toluene removed under vacuum
additionafter each addition

출처 및 근거

ORD 기록: ord-f52a5f30c1274583bbccaa857c73afbc
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05733905

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