4-Aminopyridine → 4-Pyridylcarbamoyl-beta-alanine ethyl ester
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[N-:8]=[C:9]=[O:10].[CH2:11]([O:13][C:14](=[O:18])[CH2:15][CH2:16]N)[CH3:12]>C(#N)C>[CH2:11]([O:13][C:14](=[O:18])[CH2:15][CH2:16][NH:8][C:9](=[O:10])[NH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1)[CH3:12]참가 물질
4
실험 절차
A solution of 1 g (10.64 mmol) of 4-aminopyridine and 2.3 g (15.9 mmol) of beta-alanine ethyl ester isocyanate in 30 ml of anhydrous acetonitrile is agitated for 20 hr at room temperature. After concentration to dryness and trituration of the resulting oily residue in ether (4 × 20 ml), 2.5 g (yield 88%) of 4-pyridylcarbamoyl-beta-alanine ethyl ester is obtained in the form of a solid having a melting point of 95° C.
후처리
- concentrationAfter concentration to dryness and trituration of the resulting oily residue in ether (4 × 20 ml)
출처 및 근거
- ORD 기록
- ord-87a00d5218a444b7b0b074f246b5a9f8
- 출처 데이터셋
- uspto-grants-1991_03
- 특허 번호
- US04997667
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