Pyridine, 2-methyl-4-nitro-, 1-oxide → HCID 178428516, 화합물

HRID 358576

반응식

HRID 358576 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][N+:3]=1[O-:11]>CO.[Pd].C>[CH3:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N+:3]=1[O-:11]

참가 물질

4

반응물 1

HCID 95291Pyridine, 2-methyl-4-nitro-, 1-oxide

생성물 1

HCID 178428516HCID 178428516, 화합물수율 96.2%

시약·촉매·용매 2

HCID 14818447Palladiumcarbon촉매HCID 887Methanol용매

실험 절차

4 g of 2-methyl-4-nitropyridine-N-oxide were dissolved in 90 ml of methanol and reduced with 1.2 g of 10% Pd/charcoal and H2. The catalyst was filtered off and the filtrate rotated in. The residue was boiled with 200 ml of ethyl acetate, filtered hot and the filtrate was mixed with 100 ml of hexane. The crystals precipitated after cooling the solution was sucked off, washed and dried. 3.1 g of 2-methyl-4-aminopyridine-N-oxide were obtained.

후처리

  1. filtrationThe catalyst was filtered off
  2. filtrationfiltered hot
  3. additionthe filtrate was mixed with 100 ml of hexane
  4. customThe crystals precipitated
  5. temperatureafter cooling the solution
  6. washwashed
  7. customdried

출처 및 근거

ORD 기록
ord-89149ce471274d54bb86c6416d849b1f
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04997835

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