Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 3-(2-Bromo-13-chloro-6-methyl-8alpha-ergolinyl)-1,1-diethylurea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Trichloroisocyanuric Acid | HCID 6909 | — |
| 반응물 | 3-(2-Bromo-6-methyl-8alpha-ergolinyl)-1,1-diethylurea | HCID 13059860 | — |
| 용매 | Trifluoroacetic acid | HCID 6422 | — |
| 생성물 | 3-(2-Bromo-13-chloro-6-methyl-8alpha-ergolinyl)-1,1-diethylurea | HCID 67788573 | — |
반응 단계
2.1 g of 3-(2-bromo-6-methyl-8alpha-ergolinyl)-1,1-diethylurea (5 mmol) and 388 mg of trichloroisocyanuric acid (1.67 mmol) are dissolved in 100 ml of trifluoroacetic acid at room temperature. After 15 minutes, ice is added, it is made alkaline with conc. ammonia and shaken out with dichloromethane. The organic phases are dried and concentrated by evaporation, the residue is chromatographed and the product crystallizes from ethyl acetate/ether, yield 480 mg (21% of theory).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411966 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-e4f87c257b9c434bb882cda9bcf99f6e |
| 출처 메모 | uspto-grants-1995_05 |