8-Aminooctanoic acid → 8-(2,5-Dichloro-3-thienylsulphonamido)octanoic Acid

반응식

[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10].[Cl:12][C:13]1[S:14][C:15]([Cl:22])=[CH:16][C:17]=1[S:18](Cl)(=[O:20])=[O:19]>>[Cl:12][C:13]1[S:14][C:15]([Cl:22])=[CH:16][C:17]=1[S:18]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10])(=[O:20])=[O:19]

참가 물질

반응물 2

HCID 660858-Aminooctanoic acid

HCID 27360942,5-Dichlorothiophene-3-sulfonyl chloride

생성물 1

HCID 200669828-(2,5-Dichloro-3-thienylsulphonamido)octanoic Acid

실험 절차

8-Aminocaprylic acid (1.0 g, 0.006 mole) was treated with 2,5-dichloro-3-thiophene sulphonyl chloride (1.58 g, 0.006 mole) according to the method described in Example 4 to give the title compound after recrystallisation from isopropanol/water (1.1 g, m.p. 92°-93° C.).

출처 및 근거

ORD 기록: ord-45be2263488a46599ac7cf730344e2d1
출처 데이터셋: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04997847

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