Piperidine → 6-Fluoro-3-hydroxy-1-methyl-4-quinolone

HRID 358680노트

반응식

HRID 358680 반응식
C([O:9][C:10]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([F:21])[CH:17]=2)[N:12]([CH3:22])[CH:11]=1)(=O)C1C=CC=CC=1.N1CCCCC1>ClCCl>[F:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH3:22])[CH:11]=[C:10]([OH:9])[C:19]2=[O:20]

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 542187166-Fluoro-1-methyl-4-oxo-1,4-dihydroquinol-3-yl benzoate

생성물 1

HCID 231280776-Fluoro-3-hydroxy-1-methyl-4-quinolone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 6-fluoro-1 -methyl-4-oxo-1 ,4-dihydro-quinol-3-yl benzoate (1.90 g), piperidine (0.9 ml) and dry dichloromethane (50 ml) was stirred under nitrogen for 24 hours at ambient temperature. The solvent was removed by distillation and the residue triturated with diethyl ether (100 ml). The resultant solid was collected by filtration to give the novel compound 6-fluoro-3-hydroxy-1-methyl-4-quinolone, m.pp. 104°-106°.

후처리

  1. customThe solvent was removed by distillation
  2. customthe residue triturated with diethyl ether (100 ml)
  3. filtrationThe resultant solid was collected by filtration

출처 및 근거

ORD 기록
ord-21bd8084f693488d94d2a08d4c529084
출처 데이터셋
uspto-grants-1991_03
특허 번호
US04997840

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