Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Phenylbutyric Acid → Methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]-benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Phenylbutyric Acid | HCID 7012 | — |
| 반응물 | 2,3,5-Trimethyl-6-nitro-1H-indole | HCID 609328 | — |
| 반응물 | Methyl 4-(6-amino-2,3,5-trimethylindol-1-ylmethyl)-3-methoxybenzoate | HCID 19744303 | — |
| 생성물 | Methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]-benzoate | HCID 19744308 | 32% |
반응 단계
Similarly, starting from methyl 4-(6-amino-2,3,5-trimethylindol-1-ylmethyl)-3-methoxybenzoate (itself obtained using the procedures described for A in Example 1 but starting from 2,3,5-trimethyl-6-nitroindole [G]) and 2-phenylbutyric acid, there was obtained methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]benzoate [Example 83] in 32% yield as a white solid; partial NMR: 0.9 (t,3H,CH2CH3), 1.2 (m,2H, CH2CH3), 3.4 (t,1H,CHPh), 7.3 (s,5H,Ph).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04997844 |
| 출처 데이터셋 | uspto-grants-1991_03 |
| ORD ID | ord-dbd3a55b4fd647e29aeb556cbbd9f713 |
| 출처 메모 | uspto-grants-1991_03 |