4-(2-Bromoethyl)-3-chloro-1,3-dihydro-2H-indol-2-one → 2H-Indol-2-one, 4-(2-bromoethyl)-1,3-dihydro-
반응식
[Br:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6](Cl)[C:7](=[O:13])[NH:8]2.O.[PH2]([O-])=O.[Na+]>[Pd].O>[Br:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][C:7](=[O:13])[NH:8]2참가 물질
5
실험 절차
4-(2'-Bromoethyl)-3-chloro-1,3-dihydro-2H-indol-2-one (23.6 g. 86 mmol), sodium hypophosphite hydrate (35 g) and 10% palladium/carbon (60% w/w wet, 2.6 g) were stirred in industrial methylated spirit (250 ml)/water (30 ml) at 80° C. The reaction was complete after 2 hours as monitored by HPLC. Inorganic components were removed by filtration and the organic solvent was removed in vaccuo. The solid residue was slurried in water (100 ml) and dried overnight to give 17.0 g (82%) of 4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one.
후처리
- customInorganic components were removed by filtration
- customthe organic solvent was removed in vaccuo
- customdried overnight
출처 및 근거
- ORD 기록
- ord-2813a718cc3647a98d0efbd87921e660
- 출처 데이터셋
- uspto-grants-1991_03
- 특허 번호
- US04997954
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