Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
m-Chloroperbenzoic acid → 6-Methylpyridine-3-carbonitrile 1-oxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 반응물 | 6-Methylpyridine-3-carbonitrile | HCID 281995 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 6-Methylpyridine-3-carbonitrile 1-oxide | HCID 19818671 | — |
반응 단계
A mixture of 6-methylnicotinonitrile (4.15 g) and 3-chloroperbenzoic acid (8.3 g) in dichloromethane (200 ml) was stirred under an argon atomosphere at room temperature for 16h. The dichloromethane was evaporated under reduced pressure and the residue purified by flash column chromatography on silica (K60), using ethyl acetate and then methanol: dichloromethane (1:9 by volume) as eluting solvent to give 5-cyano-2-methylpyridine-1-oxide, mp 133.5°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04999364 |
| 출처 데이터셋 | uspto-grants-1991_03 |
| ORD ID | ord-a78378da87434bf7a8573388e582ea7e |
| 출처 메모 | uspto-grants-1991_03 |