Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 4-[1-(4-fluorophenyl)-1H-indazol-3-yl]-1-piperazine carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Nitrourea | HCID 62372 | — |
| 반응물 | 1-(4-fluorophenyl)-3-(1-piperazinyl)-1H-indazole | HCID 15117082 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-[1-(4-fluorophenyl)-1H-indazol-3-yl]-1-piperazine carboxamide | HCID 15117100 | 47.2% |
반응 단계
A mixture of 5.0 g of 1-(4-fluorophenyl)-3-(1-piperazinyl)-1H-indazole, 5.1 g of nitrourea, and 80 ml of dimethylformamide was heated on a steam bath for 15 minutes. The reaction mixture was then poured into water and the resulting precipitate was recrystallized from ethyl acetate (2×) to yield 2.7 g (47%) of 4-[1-(4-fluorophenyl)-1H-indazol-3-yl]-1-piperazine carboxamide, m.p. 148°-150°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04999356 |
| 출처 데이터셋 | uspto-grants-1991_03 |
| ORD ID | ord-6046f9ba4ad845dfa8c513c688871ada |
| 출처 메모 | uspto-grants-1991_03 |