Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-[2-Hydroxyadamant-1-yl-1-(imidazolyl)methyl]benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Adamantanone | HCID 64151 | — |
| 반응물 | Lithium diisopropylamide | HCID 2724682 | — |
| 반응물 | 4-(1-Imidazolylmethyl)benzonitrile | HCID 11148102 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-[2-Hydroxyadamant-1-yl-1-(imidazolyl)methyl]benzonitrile | HCID 19939524 | — |
반응 단계
5.0 g of 4-[1-(imidazolyl)methyl]benzonitrile is dissolved in 100 ml of tetrahydrofuran and combined at -50° with 20 ml of 1.5-molar solution of lithium diisopropylamide in tetrahydrofuran, stirred for 0.5 hour at -60° combined With 4 3 g of 2-adamantanone, further stirred for 1 hour, and heated to 25°. Then water is added, the mixture is extracted three times with ethyl acetate, washed neutral with water, dried over sodium sulfate, and concentrated to dryness under vacuum, thus obtaining 6.66 g of crude 4-[2-hydroxy-adamant-1-yl-1-(imidazolyl)methyl]benzonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411982 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-377e765bff1143e593a7d59d89ccb6b9 |
| 출처 메모 | uspto-grants-1995_05 |