Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → HCID 178509720, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Cycloheptanone | HCID 10400 | — |
| 반응물 | Lithium diisopropylamide | HCID 2724682 | — |
| 반응물 | HCID 178509721 | HCID 178509721 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 178509720 | HCID 178509720 | 98.2% |
반응 단계
5 g of 4-[1-(1,2,4-triazolyl)methyl]benzonitrile is dissolved in 100 ml of tetrahydrofuran and combined at -50° with 19.8 ml of 1.5-molar solution of lithium diisopropylamide in tetrahydrofuran, stirred for 0.5 hour, further stirred for 1 hour at -70° with 3.05 g of cycloheptanone, and heated to 25°. Then the mixture is combined with water, extracted twice with ethyl acetate, washed neutral with water, dried over sodium sulfate, and concentrated to dryness under vacuum, thus obtaining 7.9 g of crude 4-[1-hydroxycyclohept-1-yl-1-(1,2,4-triazolyl) methyl]benzonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411982 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-fbb1f373f49f4069a88ae022b4f78436 |
| 출처 메모 | uspto-grants-1995_05 |