Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → HCID 178509717, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Adamantanone | HCID 64151 | — |
| 반응물 | Lithium diisopropylamide | HCID 2724682 | — |
| 반응물 | HCID 178509721 | HCID 178509721 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 178509717 | HCID 178509717 | 99.1% |
반응 단계
5 g of 4-[1-(1,2,4-triazolyl)methyl]benzonitrile is dissolved in 100 ml of tetrahydrofuran and combined at -50° with 19.8 ml of 1.5-molar solution of lithium diisopropylamide in tetrahydrofuran, stirred for 0.5 hour, further stirred with 4.25 g of adamantanone for 1 hour at -70°, and heated to 25°. Then water is added, the mixture is extracted twice with ethyl acetate, washed neutral with water, dried over sodium sulfate, and concentrated to dryness under vacuum, yielding 9 g of crude 4-(2-hydroxyadamant-2-yl-1(1,2,4-triazolyl)methyl]benzonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411982 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-790cc1ed03c34f3892fab8140e2d2c08 |
| 출처 메모 | uspto-grants-1995_05 |