Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-(Azidomethyl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| 용매 | 1,3-Dimethyl-2-imidazolidinone | HCID 6661 | — |
| 생성물 | 4-(Azidomethyl)benzonitrile | HCID 11073691 | 96.7% |
반응 단계
50 g of 4-bromomethylbenzonitrile is dissolved in 350 ml of 1,3-dimethyl-2-imidazolidinone and stirred at 25° for 2 hours with 32.5 g of sodium azide. The mixture is subsequently combined with 500 ml of water under ice cooling, extracted twice with dichloromethane, washed with water, dried over sodium sulfate, concentrated to dryness under vacuum, and chromatographed on silica gel with hexane/ethyl acetate, thus obtaining 39 g of 4-azidomethylbenzonitrile as a colorless liquid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411982 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-c905a16c14b340969660360c09b93391 |
| 출처 메모 | uspto-grants-1995_05 |