Cyclopentylurea → HCID 20064769, 화합물

HRID 359275

반응식

HRID 359275 반응식
[CH:1]1([NH:6][C:7]([NH2:9])=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH:11]([C:17]([C:19]([F:22])([F:21])[F:20])=O)[C:12]([O:14][CH2:15][CH3:16])=[O:13]>>[CH:1]1([NH:6][C:7]2[O:8][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:17]([C:19]([F:20])([F:22])[F:21])[N:9]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 294526CyclopentylureaHCID 2737165Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate

생성물 1

HCID 20064769HCID 20064769, 화합물수율 34.2%

실험 절차

By the procedure of Example 4, 7.68 g (60 mmol) of cyclopentyl urea was reacted with 10.9 g (50 mmol) of ethyl 2-chloro-4,4,4-trifluoroacetoacetate at 140°-150° C. for 18 hours. The product was separated and then recrystallized from methylcyclohexane to yield 5.0 g of a white solid product (m.p.=41°-42° C.) identified in Table I.

후처리

  1. customThe product was separated
  2. customrecrystallized from methylcyclohexane

출처 및 근거

ORD 기록
ord-25bb2e3ba19a4f42b112e723be3b6887
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05000775

연결된 노트

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