Allylurea → Ethyl 2-(2-propenylamino)-4-(trifluoromethyl)-5-oxazolecarboxylate

HRID 359277

반응식

HRID 359277 반응식
[CH2:1]([NH:4][C:5]([NH2:7])=[O:6])[CH:2]=[CH2:3].Cl[CH:9]([C:15]([C:17]([F:20])([F:19])[F:18])=O)[C:10]([O:12][CH2:13][CH3:14])=[O:11]>>[CH2:1]([NH:4][C:5]1[O:6][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:15]([C:17]([F:18])([F:20])[F:19])[N:7]=1)[CH:2]=[CH2:3]

참가 물질

3

반응물 2

HCID 11181AllylureaHCID 2737165Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate

생성물 1

HCID 20064750Ethyl 2-(2-propenylamino)-4-(trifluoromethyl)-5-oxazolecarboxylate수율 36.1%

실험 절차

By the procedure of Example 4, 6 g (60 mmol) of allyl urea was reacted with 10.9 g (50 mmol) of ethyl 2-chloro-4,4,4-trifluoroacetoacetate at 140°-150° C. for 18 hours. The product was separated and then recrystallized from methylcyclohexane to yield 4.77 g of a yellow solid product (m.p.=48°-49° C.) identified in Table I.

후처리

  1. customThe product was separated
  2. customrecrystallized from methylcyclohexane

출처 및 근거

ORD 기록
ord-c3b9ca97a4ee47c898952b886e3f5cdb
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05000775

연결된 노트

불러오는 중…