Propylurea → Ethyl 2-(propylamino)-4-(trifluoromethyl)-5-oxazolecarboxylate

반응식

[CH2:1]([NH:4][C:5]([NH2:7])=[O:6])[CH2:2][CH3:3].Cl[CH:9]([C:15]([C:17]([F:20])([F:19])[F:18])=O)[C:10]([O:12][CH2:13][CH3:14])=[O:11]>>[CH2:1]([NH:4][C:5]1[O:6][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:15]([C:17]([F:18])([F:20])[F:19])[N:7]=1)[CH2:2][CH3:3]

참가 물질

반응물 2

HCID 12303Propylurea

HCID 2737165Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate

생성물 1

HCID 20064732Ethyl 2-(propylamino)-4-(trifluoromethyl)-5-oxazolecarboxylate수율 17.3%

실험 절차

By the procedure of Example 4, 6.13 g (60 mmol) of n-propyl urea was reacted with 10.9 g (50 mmol) of ethyl 2-chloro-4,4,4-trifluoroacetoacetate at 140°-150° C. for 18 hours. The product was separated and then recrystallized from n-heptane to yield 2.3 g of a yellow powder product (m.p.=33°-34° C.) identified in Table I.

후처리

customThe product was separated
customrecrystallized from n-heptane

출처 및 근거

ORD 기록: ord-d8a766a8b17f4de8b8880790b30fba54
출처 데이터셋: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05000775

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