Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 2,2-Dimethylcyclopentanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 생성물 | 2,2-Dimethylcyclopentanone | HCID 138286 | — |
| 생성물 | 6,6-Dimethylpiperidin-2-one | HCID 1714407 | — |
반응 단계
The oxime of 2,2 dimethylcyclopentanone is prepared by reaction of the ketone with hydroxylamine hydrochloride in EtOH, and treated with p-toluenesulfonyl chloride and DMAP. Heating then effects Beckmann rearrangement to give 6,6-dimethyl-2-piperidinone which is deprotonated with NaH in DMF solution. Reaction with n-butyl iodide then gives the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05001113 |
| 출처 데이터셋 | uspto-grants-1991_03 |
| ORD ID | ord-a010d9c3c9ea409e9b454f9466a6ce01 |
| 출처 메모 | uspto-grants-1991_03 |