Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nilutamide → 5,5-Dimethyl-3-(4-nitro-3-trifluoromethyl-phenyl)-1-nonyl-2,4-imidazolidinedione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nilutamide | HCID 4493 | — |
| 반응물 | 1-Bromononane | HCID 12742 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 생성물 | 5,5-Dimethyl-3-(4-nitro-3-trifluoromethyl-phenyl)-1-nonyl-2,4-imidazolidinedione | HCID 22116951 | — |
반응 단계
Using the procedure of Example 1, 1 g of 1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl imidazolidine-2,5-dione was reacted with a 50% suspension of 170 mg of sodium hydride in oil and 0.7 ml of 1-bromo-nonane to obtain after chromatography on silica 1.08 g of the desired product melting at 63° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411981 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-ff946c18220b4bed99f4df292ed2a703 |
| 출처 메모 | uspto-grants-1995_05 |