Sodium Carbonate → HCID 19095594, 화합물

HRID 359439노트

반응식

HRID 359439 반응식
Cl.[Cl:2][C:3]1[N:4]=[N:5][C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:7][CH:8]=1.C(=O)([O-])[O-].[Na+].[Na+].CN(C)C(=O)C.Br[CH2:28][CH2:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>O>[ClH:2].[Cl:2][C:3]1[N:4]=[N:5][C:6]([N:9]2[CH2:10][CH2:11][N:12]([CH2:28][CH2:29][CH2:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:13][CH2:14]2)=[CH:7][CH:8]=1

참가 물질

6

반응물 4

HCID 10340Sodium CarbonateHCID 12503(3-Bromopropyl)benzeneHCID 31374DimethylacetamideHCID 122375913-Chloro-6-piperazinopyridazine Hydrochloride

생성물 1

HCID 19095594HCID 19095594, 화합물수율 60%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

A mixture of 3.6 parts of 3-chloro-6-(1-piperazinyl)pyridazine monohydrochloride, 5.3 parts of sodium carbonate and 90 parts of N,N-dimethylacetamide was stirred for a while at 60° C. Then there were added 3 parts of (3-bromopropyl)benzene and the whole was stirred overnight at 60° C. The reaction mixture was poured into water. The product was filtered off and converted into the hydrochloride salt in 2-propanol. The salt was filtered off and dried, yielding 3.2 parts (60%) of 3-chloro-6-[4-(3-phenylpropyl)-1-piperazinyl]pyridazine monohydrochloride; mp. 207.3° C. (compound 226) In a similar manner there were also prepared:

후처리

  1. stirringthe whole was stirred overnight at 60° C
  2. filtrationThe product was filtered off
  3. filtrationThe salt was filtered off
  4. customdried

출처 및 근거

ORD 기록
ord-6e32e00587104788b61d3ff4dc872b26
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05001125

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