Imidazole → 1-[[3-[[3-(Hexadecyloxy)-2-methoxypropoxy]methyl]phenyl]methyl]-1H-imidazol

HRID 35953

반응식

HRID 35953 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][O:10][CH2:11][CH:12]([O:31][CH3:32])[CH2:13][O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH:4]=1.[NH:33]1[CH:37]=[CH:36][N:35]=[CH:34]1>C1(C)C=CC=CC=1>[CH2:15]([O:14][CH2:13][CH:12]([O:31][CH3:32])[CH2:11][O:10][CH2:9][C:5]1[CH:4]=[C:3]([CH2:2][N:33]2[CH:37]=[CH:36][N:35]=[CH:34]2)[CH:8]=[CH:7][CH:6]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 199395571-(Bromomethyl)-3-[[3-(hexadecyloxy)-2-methoxypropoxy]methyl]benzene

생성물 1

HCID 199395461-[[3-[[3-(Hexadecyloxy)-2-methoxypropoxy]methyl]phenyl]methyl]-1H-imidazol수율 86.3%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
80 °C

실험 절차

a mixture of 2.4 g of 1-(bromomethyl)-3-[[3-(hexadecyloxy)-2-methoxypropoxy]methyl]benzene, 2.54 g of imidazole and 30 ml of toluene was heated at 80° C. under argon in a pressure bottle for 4 hours and then evaporated. The residue was purified by chromatography, giving 2.02 g of the desired product as a colorless oil.

후처리

  1. customevaporated
  2. customThe residue was purified by chromatography

출처 및 근거

ORD 기록
ord-786f211439ef46fe9014490b5ebd34f7
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05411983

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