Potassium Carbonate → N-[2-(2-methylpropoxy)phenyl]-3-(trifluoromethyl)benzamide

HRID 359541노트

반응식

HRID 359541 반응식
[F:1][C:2]([C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1C(Cl)=O)([F:4])[F:3].[CH3:14][CH:15]([CH3:25])[CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[NH2:24].[C:26](=O)([O-])[O-:27].[K+].[K+]>ClCCl>[CH3:14][CH:15]([CH3:25])[CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[NH:24][C:26](=[O:27])[C:12]1[CH:11]=[CH:10][CH:6]=[C:5]([C:2]([F:1])([F:3])[F:4])[CH:13]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 675612-(Trifluoromethyl)benzoyl chlorideHCID 13654662(2-Isobutoxyphenyl)amine

생성물 1

HCID 14405584N-[2-(2-methylpropoxy)phenyl]-3-(trifluoromethyl)benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 12.5 g of 3.(trifluoromethyl)benzoyl chloride in 60 ml of dichloromethane is added dropwise to a suspension of 9.9 g of 2-(2-methylpropoxy)benzenamine and 33 g of potassium carbonate in 90 ml of dichloromethane, cooled in an ice-bath.

후처리

  1. temperaturecooled in an ice-bath

출처 및 근거

ORD 기록
ord-10aee65a7c594b228059886e0d0602f6
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05001159

반응 노트

불러오는 중…