Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-Fluoro-2-methylthionaphthacene-5,12-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Sodium methanethiolate | HCID 4378561 | — |
| 반응물 | 2,3-Difluoronaphthacene-5,12-dione | HCID 20089834 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-Fluoro-2-methylthionaphthacene-5,12-dione | HCID 20065415 | — |
반응 단계
1 g (3.4 mmol) of 2,3-difluoronaphthacene-5,12-dione, 0.94 g (6.8 mmol) of potassium carbonate, 0.47 g (6.8 mmol) of sodium methanethiolate and 20 ml of tetrahydrofuran are stirred at 25° C. for 2.5 hours. The mixture is poured into dilute hydrochloric acid and extracted with THF/toluene. The organic phase is dried over sodium sulfate and evaporated. The residue is chromatographed on silica gel with toluene. Yield 0.55 g (50%); melting point 230°-235° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05001243 |
| 출처 데이터셋 | uspto-grants-1991_03 |
| ORD ID | ord-93a7efa5fd9e40e4a3b25ddb4ec45ece |
| 출처 메모 | uspto-grants-1991_03 |