3-(Aminomethyl)-5-bromopyridine → 5-Bromo-6-[[(5-bromo-3-pyridinyl)methyl]amino]-2-methyl-4(3H)-pyrimidone
반응식
[Br:1][C:2]1[C:3]([OH:10])=[N:4][C:5]([CH3:9])=[N:6][C:7]=1Cl.[NH2:11][CH2:12][C:13]1[CH:14]=[C:15]([Br:19])[CH:16]=[N:17][CH:18]=1>COCCOC>[Br:1][C:2]1[C:3](=[O:10])[NH:4][C:5]([CH3:9])=[N:6][C:7]=1[NH:11][CH2:12][C:13]1[CH:18]=[N:17][CH:16]=[C:15]([Br:19])[CH:14]=1참가 물질
4
반응 조건
- 온도
- 23 °C
실험 절차
A stirred mixture of 5-bromo-6-chloro-2-methyl-4-pyrimidinol (4.54 g, 20.3 mmol) and 5-aminomethyl-3-bromopyridine (11.4 g, 61.0 mmol) in 1,2-dimethoxyethane (40 mL) was heated at reflux for 18 hours. The mixture was cooled to 23° C. The precipitate which formed was isolated, rinsed with 1,2-dimethoxyethane and water, and then recrystallized from methanol to provide the title compound as a white, analytically pure product (5.16 g, 13.8 mmol, 68% of theory): mp 241-242 C.; Rf 0.62 (20% MeOH in EtOAc); 1H NMR (DMSO-D6, 400 MHz)δ8.56 (d, J=2 Hz, 1H), 8.49 (d, J=2 Hz, 1H), 7.92 (m, 1H), 7.33 (t, J=6 Hz, 1H), 4.55 (d, J=6 Hz, 2H), 2.16 (s, 3H); IR (KBr) 3400 (NH), 2700-3000 (CH), 1640 (C=O) cm-1 ; UV (MeOH)λ278 (ε12,400); mass spectrum m/e 372 (M+, 54%), 374 (M+, 100%), 376 (M+, 52%), 185 (C6H6BrN2, 78%).