Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Captopril → N-(1-Naphthyl)ethylenediamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Captopril | HCID 44093 | — |
| 반응물 | S-Nitrosocaptopril | HCID 129596 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 용매 | Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl ester | HCID 613145 | — |
| 생성물 | N-(1-Naphthyl)ethylenediamine | HCID 15107 | — |
반응 단계
Typical preparations of S-nitrosocaptopril involve the reaction of 50 mM captopril with 50 mM NaNO2 in 0.1 N acetic or sulfuric acid at room temperature for five minutes, after which the reaction solution is passed over a cation exchange resin, e.g., Dowex 50 in the protonated form, and the product eluted with water. The fractions that give positive reactions with N-(1-naphthyl)ethylenediamine, after exposure to 0.15% HgCl2 and diazotization with sulfanilamide, are lyophilized. Hygroscopic, bright red crystals were obtained that were
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05002964 |
| 출처 데이터셋 | uspto-grants-1991_03 |
| ORD ID | ord-855e4ea735f84408958842a4e014961c |
| 출처 메모 | uspto-grants-1991_03 |