2-Bromopropanoyl chloride → HCID 14750700, 화합물

HRID 359867

반응식

HRID 359867 반응식
[C:1]1([C:7]2([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[NH:11][C:10](=[O:12])[N:9]([CH2:13][OH:14])[C:8]2=[O:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:22][CH:23]([CH3:27])[C:24](Cl)=[O:25]>C(OCC)C>[Br:22][CH:23]([CH3:27])[C:24]([O:14][CH2:13][N:9]1[C:8](=[O:15])[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:11][C:10]1=[O:12])=[O:25]

참가 물질

4

반응물 2

HCID 979802-Bromopropanoyl chlorideHCID 1613663-(Hydroxymethyl)phenytoin

생성물 1

HCID 14750700HCID 14750700, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

5,5-Diphenyl-3-hydroxymethyl-2,4-imidazolidinedione (2 g, 0.0071 mol) was dissolved in 2-bromopropionyl chloride (8.5 g, 5 mL, 0.05 mol) by heating for 30 minutes on a 100°-110° C. oil bath. The reaction mixture was cooled, 20 mL of ethyl ether were added, and the resultant solution was extracted with aqueous potassium carbonate, dried and then crystallized. The product was obtained as a solid white substance (1 g, 34%), m.p. 112°-115° C. Anal. calc. for C19H17N2O4Br: C, 54.69; H, 4.11; N, 6.72; Br, 19.15. Found: C, 54.77; H, 4.15; N, 6.69; Br, 19.25. The product had the formula: ##STR77##

후처리

  1. temperatureby heating for 30 minutes on a 100°-110° C. oil bath
  2. temperatureThe reaction mixture was cooled
  3. extractionthe resultant solution was extracted with aqueous potassium carbonate
  4. customdried
  5. customcrystallized
  6. customThe product was obtained as a solid white substance (1 g, 34%), m.p. 112°-115° C

출처 및 근거

ORD 기록
ord-908a4061766d43b2996171ba139d08cc
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05002935

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