Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Estradiol → Estradiol-dinicate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Estradiol | HCID 5757 | — |
| 반응물 | Nicotinoyl chloride | HCID 82604 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | Estradiol-dinicate | HCID 13731090 | 90.3% |
반응 단계
To 5.3 g (0.03 mol) of nicotinoyl chloride in 30 mL of dry pyridine at 0° C. were added 2.0 g (0.0073 mol) of β-estradiol. The reaction mixture was refluxed for 1 hour, then was poured over 100 mL of ice water, and the resulting precipitate was collected by filtration. The precipitate was dried in vacuo over P2O5, affording 3.18 g (90%) of the title compound melting at 148°-150° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05002935 |
| 출처 데이터셋 | uspto-grants-1991_03 |
| ORD ID | ord-f4a3df2419d54ec0bd33f45986ae534d |
| 출처 메모 | uspto-grants-1991_03 |