Protocatechuic Acid → Benzhydryl protocatechuate

HRID 359912

반응식

HRID 359912 반응식
[C:1]([OH:11])(=[O:10])[C:2]1[CH:9]=[CH:8][C:6]([OH:7])=[C:4]([OH:5])[CH:3]=1.[C:12]1([C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[N+]=[N-])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(OCC)(=O)C>[C:1]([O:11][CH:18]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(=[O:10])[C:2]1[CH:9]=[CH:8][C:6]([OH:7])=[C:4]([OH:5])[CH:3]=1

참가 물질

4

반응물 2

HCID 72Protocatechuic AcidHCID 612301,1'-(Diazomethylene)bis(benzene)2회

생성물 1

HCID 20064320Benzhydryl protocatechuate수율 55.9%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Ethyl acetate (2.5 ml) was mixed with 50.0 mg of protocatechuic acid and 63.0 mg of diphenyldiazomethane to form a solution. The solution was left over at room temperature for 2 hours. Diphenyldiazomethane (25.8 mg) was added further and the resultant mixture was left over at room temperature for 2 hours. The pale reddish purple-colored reaction solution was concentrated under reduced pressure, and the colorless residue obtained was purified by chromatography on a silica gel column {developer: chloroform - chloroform-methanol (30:1)} to obtain 58.1 mg of the titled compound as a colorless syrup. EIMS: m/z 320 (M+).

후처리

  1. customto form a solution
  2. concentrationThe pale reddish purple-colored reaction solution was concentrated under reduced pressure
  3. customthe colorless residue obtained
  4. customwas purified by chromatography on a silica gel column {developer

출처 및 근거

ORD 기록
ord-cb34b8eff5a74ceabbecd679b18e1036
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05003055

연결된 노트

불러오는 중…