Bromotrimethylsilane → HCID 14626581, 화합물
반응식
[CH3:1][Si:2](Br)([CH3:4])[CH3:3].[F:6][C:7]1[CH:13]=[CH:12][CH:11]=[C:10]([F:14])[C:8]=1[NH2:9]>C1C=CC=CC=1>[CH3:1][Si:2]([CH3:4])([CH3:3])[NH:9][C:8]1[C:7]([F:6])=[CH:13][CH:12]=[CH:11][C:10]=1[F:14]참가 물질
4
실험 절차
Trimethylsilyl bromide, 10.24 ml (77.5 mmole), was added to 6 ml (55.7 mmole) of 2,6-difluoroaniline in 70 ml of benzene. There was a slight exotherm and immediate precipitation. Triethylamine, 10.8 ml (77.5 mmole), was added and the mixture stirred at room temperature for 16 hours. The mixture was filtered and the solvent removed from the filtrate in vacuo. The product was purified as described in Example 1 to provide 8.85 g (51.1 mmole, 91.7 percent yield) of 99.3 percent pure N-trimethylsilyl-2,6-difluoroaniline as a colorless liquid, b.p. 89°-91° C. at 18 mm.
후처리
- customa slight exotherm and immediate precipitation
- additionTriethylamine, 10.8 ml (77.5 mmole), was added
- filtrationThe mixture was filtered
- customthe solvent removed from the filtrate in vacuo
- customThe product was purified
출처 및 근거
- ORD 기록
- ord-aea22da04f1a42bf901f39e5fea855bb
- 출처 데이터셋
- uspto-grants-1991_03
- 특허 번호
- US05003096
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