Dimethylacetamide → Quinoline

HRID 359963

반응식

HRID 359963 반응식
F[C:2]1[CH:3]=[C:4]2[C:9](=O)OC(=O)[C:5]2=[CH:11][C:12]=1F.[F:14][C:15]1[CH:16]=[C:17]([C:25]([OH:27])=[O:26])[C:18](=[CH:22][C:23]=1[F:24])C(O)=O.[CH3:28][C:29]([N:31](C)C)=O>CN1CCCC1=O>[N:31]1[C:5]2[C:4](=[CH:3][CH:2]=[CH:12][CH:11]=2)[CH:9]=[CH:28][CH:29]=1.[F:14][C:15]1[CH:16]=[C:17]([CH:18]=[CH:22][C:23]=1[F:24])[C:25]([OH:27])=[O:26]

참가 물질

6

반응물 3

HCID 31374DimethylacetamideHCID 6397454,5-Difluorophthalic AnhydrideHCID 6433824,5-Difluorophthalic Acid

생성물 2

HCID 7047QuinolineHCID 991663,4-Difluorobenzoic acid

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

Surprisingly, we have found that 4,5-difluorophthalic anhydride and 4,5-difluorophthalic acid may be selectively decarboxylated in N-methyl-pyrrolidone, dimethyl acetamide or quinoline to yield 3,4-difluorobenzoic acid.

출처 및 근거

ORD 기록
ord-e5f44cf93a7c49a0ba418940a37b3b97
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05003103

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