Terazosin Hydrochloride → 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate

HRID 35999

반응식

HRID 35999 반응식
O.O.[ClH:3].[NH2:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:17][CH3:18])=[C:12]([O:15][CH3:16])[CH:13]=2)[N:8]=[C:7]([N:19]2[CH2:24][CH2:23][N:22]([C:25]([CH:27]3[CH2:31][CH2:30][CH2:29][O:28]3)=[O:26])[CH2:21][CH2:20]2)[N:6]=1>CO>[CH3:12][O-:15].[ClH:3].[NH2:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:17][CH3:18])=[C:12]([O:15][CH3:16])[CH:13]=2)[N:8]=[C:7]([N:19]2[CH2:24][CH2:23][N:22]([C:25]([CH:27]3[CH2:31][CH2:30][CH2:29][O:28]3)=[O:26])[CH2:21][CH2:20]2)[N:6]=1

참가 물질

3

반응물 1

HCID 63016Terazosin Hydrochloride

생성물 1

HCID 867486641-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate수율 87%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride dihydrate (7.37. g, 16.0 mmol, prepared in accordance with the teachings of U.S. Pat. No. 4,25 1,532) was placed in an Edenmeyer flask and dissolved in a minimum amount (about 10 mL) of hot dry methanol. The solid initially dissolved, but soon turned cloudy and a precipitate formed. The precipitate was collected by filtration and washed with a small quantity of dry methanol followed by dry acetone to yield 6.35 g (13.9 mmol, 87.0%) of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate.

후처리

  1. customg, 16.0 mmol, prepared in accordance with the teachings of U.S
  2. dissolutionThe solid initially dissolved
  3. customa precipitate formed
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with a small quantity of dry methanol

출처 및 근거

ORD 기록
ord-0d1412ab4e3b409890ef460da4092292
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05412095

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