Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanethiol → Ethyl 2-butyl-1-[[2'-(methoxycarbonyl)-(1,1'-biphenyl)-4-yl]-methyl]-4-(methylthio)-1H-imidazole-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanethiol | HCID 878 | — |
| 반응물 | Ethyl 2-butyl-5-methylsulfanyl-3H-imidazole-4-carboxylate | HCID 9859628 | — |
| 반응물 | Methyl 4'-(bromomethyl)biphenyl-2-carboxylate | HCID 11012181 | — |
| 생성물 | Ethyl 2-butyl-1-[[2'-(methoxycarbonyl)-(1,1'-biphenyl)-4-yl]-methyl]-4-(methylthio)-1H-imidazole-5-carboxylate | HCID 21479063 | 69.3% |
반응 단계
The operation is carried out as in Example 5, starting with 0.6 g of ethyl 2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate (prepared as indicated in Stages C and D of Preparation 1, replacing the ethanethiol with methanethiol), using 907 mg of methyl 4'-(bromomethyl)-(1,1'-biphenyl)-2 -carboxylate. After chromatography on silica (eluant: methylene chloride--ethyl acetate (97-3)), 0.8 g of the desired product is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05412101 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-473075b184e64b86bdfbb71dc68452bf |
| 출처 메모 | uspto-grants-1995_05 |