Nitric Acid → 2-Amino-3,5-dinitropyridine

HRID 36113

반응식

HRID 36113 반응식
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6](C)[CH:5]=[CH:4][N:3]=1.[N+:12]([O-])([OH:14])=[O:13]>OS(O)(=O)=O>[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([N+:12]([O-:14])=[O:13])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 2431662-Amino-4-methyl-3-nitropyridine

생성물 1

HCID 5043402-Amino-3,5-dinitropyridine

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

To a stirred solution of 2-amino-3-nitro-4-methylpyridine (25.6 g, 167 mmol) in conc. H2SO4 (100 mL) at 0° C. was added HNO3 (7.77 mL, d=1.49) dropwise over 30 min. The mixture was warmed to r.t. for 20 min then heated to 45° C. for 90 min. The reaction mixture was cooled and poured into 500 g of ice. The resulting percipitate was filtered and air dried to give 2-amino-3,5-dinitropyridine as a yellow solid.

후처리

  1. temperaturethen heated to 45° C. for 90 min
  2. temperatureThe reaction mixture was cooled
  3. filtrationThe resulting percipitate was filtered
  4. customair dried

출처 및 근거

ORD 기록
ord-71de3f2a2c5d471f94b305a41cd2559c
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05412097

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