Phenyl isocyanate → 4-[[(Dimethylamino)methylene]amino]-3-pyridinol phenylcarbamate

HRID 361334

반응식

HRID 361334 반응식
[CH3:1][N:2]([CH:4]=[N:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[OH:12])[CH3:3].[C:13]1([N:19]=[C:20]=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>O1CCCC1>[C:13]1([NH:19][C:20]([O:12][C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:6]=2[N:5]=[CH:4][N:2]([CH3:1])[CH3:3])=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 153809294-[[(Dimethylamino)methylene]amino]-3-pyridinol

생성물 1

HCID 677490644-[[(Dimethylamino)methylene]amino]-3-pyridinol phenylcarbamate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a warm solution of 4-[[(dimethylamino)methylene]amino]-3-pyridinol (3.0 g) in dry tetrahydrofuran (60 mL) was added phenyl isocyanate (2.05 mL). The reaction mixture was stirred at room temperature for 1.5 hours and filtered. The solid was washed with dry diethyl ether, air dried, and dried under high vacuum and refluxing ethanol for 4 hours to yield 4.19 g of solid, m.p. 151° C.

후처리

  1. filtrationfiltered
  2. washThe solid was washed with dry diethyl ether, air
  3. customdried
  4. customdried under high vacuum
  5. temperaturerefluxing ethanol for 4 hours

출처 및 근거

ORD 기록
ord-5346322bd6644f4ba5dfc813f96a7685
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05866565

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