Sodium ethoxide → HCID 22478414, 화합물

HRID 361361노트

반응식

HRID 361361 반응식
Br[CH2:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][N:7]=[C:6]2[NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=1.[Na].[SH:22][C:23]1[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=1.SC1N(C)C=CN=1.[O-]CC.[Na+]>C(O)C>[CH3:20][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][CH:17]=1)[NH:13][C:6]1[C:5]2[C:10](=[CH:11][CH:12]=[C:3]([CH2:2][S:22][C:23]3[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=3)[CH:4]=2)[N:9]=[CH:8][N:7]=1

참가 물질

6

반응물 4

HCID 2723922Sodium ethoxideHCID 224784026-Bromomethyl-4-(3-methylanilino)quinazolineHCID 178480602HCID 178480602, 화합물HCID 178480605HCID 178480605, 화합물

생성물 1

HCID 22478414HCID 22478414, 화합물수율 65%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Using an analogous procedure to that described in Example 34, 6-bromomethyl-4-(3-methylanilino)quinazoline was reacted with 2-mercapto-1-methylimidazole sodium salt [prepared by the reaction of 2-mercapto-1-methylimidazole and sodium ethoxide in ethanol] to give 4-(3-methylanilino)-6-(N-methylimidazol-2-ylthiomethyl)quinazoline in 65% yield, m.p. 137°-139° C.;

출처 및 근거

ORD 기록
ord-28d24411b2844d93b767b7f87b1c7aad
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05866572

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