참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | p-(Trifluoromethoxy)phenol | HCID 70015 | — |
| 반응물 | 1-Octanol, 8-bromo- | HCID 162607 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 8-(4-(Trifluoromethoxy)-phenoxy)-1-octanol | HCID 22407929 | — |
반응 단계
A mixture of 5.0 g of 4-(trifluoromethoxy)phenol, 5.87 g of 8-bromo-1-octanol, and 7.76 g of K2CO3 in 56 ml of anhydrous dimethylformamide is stirred and heated at 80° C. for 16 hours. The reaction mixture is poured into dilute HCl solution and the mixture is extracted three times with ethyl acetate. The combined extracts are washed with brine and dried over MgSO4. After filtration and concentration, the crude product is purified by flash chromatography on silica gel, eluting with a 4:1 hexane/ethyl acetate mixture to give the title compound 8-(4-(trifluoromethoxy)-phenoxy)-1-octanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05412137 |
|---|
| 출처 데이터셋 | uspto-grants-1995_05 |
|---|
| ORD ID | ord-a10137d50be249069508be380a70b375 |
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| 출처 메모 | uspto-grants-1995_05 |
|---|
