Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → (R)-2-azido-1-benzylethylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | 1-azido-2-(R)-(BOC-amino)-3-phenylpropane | HCID 22941732 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (R)-2-azido-1-benzylethylamine | HCID 14802497 | 78.9% |
반응 단계
The compound from step 164c (4.3 g, 15.6 mmol) was dissolved in 30 mL of 4N HCl in ethanol, and the reaction mixture was stirred for 1.5 hours at room temperature. The solvent was stripped and chased with ether. The residue was dissolved in water, NaCl was added, and the mixture was extracted with ethyl ether, which was discarded. The aqueous layer was adjusted to pH 12 with K2CO3, saturated with NaCl, then extracted with CHCl3. The organic extract was washed with brine, dried (Na2SO4) and filtered. The solvent was removed under vacuum to afford 2.17 g of the title compound. MS m/z (M+H)+ : 177, MS m/z (M+NH4)+ : 194.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05866549 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-945ea424ab244a6187c5dfdeb60280c6 |
| 출처 메모 | uspto-grants-1999_02 |