Ammonia → 5,6-Dihydro-7,7-Dimethyl-3-nitro-cyclopenta[b]pyridine
반응식
C[N:2]1[CH:7]=[C:6]([N+]([O-])=O)[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[C:3]1=O.[CH3:15][C:16]1(C)[CH2:20]C[CH2:18][C:17]1=O.N>CO>[CH3:15][C:16]1([CH3:20])[C:7]2=[N:2][CH:3]=[C:4]([N+:11]([O-:13])=[O:12])[CH:5]=[C:6]2[CH2:18][CH2:17]1참가 물질
5
실험 절차
A mixture of 1-methyl-3,5-dinitro-2-pyridone (0.8 g, 4.0 mmol), 2,2-dimethyl-cyclopentanone (0.45 g, 4.0 mmol) and ammonia solution (2.0M) in methanol (40 mL) was refluxed overnight. The solvent was removed in vacuo and the residue was dissolved in ethyl acetate. The soluble portion was flash chromatographed over silica gel (eluent 90:10 v/v ethyl acetate-hexane) to give a yellow solid (0.183 g, 24% yield).
후처리
- temperaturewas refluxed overnight
- customThe solvent was removed in vacuo
- dissolutionthe residue was dissolved in ethyl acetate
- customchromatographed over silica gel (eluent 90:10 v/v ethyl acetate-hexane)
출처 및 근거
- ORD 기록
- ord-66ed24339d9542aeb83127d522d74002
- 출처 데이터셋
- uspto-grants-1999_02
- 특허 번호
- US05866579
반응 노트
불러오는 중…