Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → (2,4-Dihydroxypyrido[3,2-d]pyrimidin-6-yl)methyl acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 반응물 | 2499-96-9 | HCID 273240 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | (2,4-Dihydroxypyrido[3,2-d]pyrimidin-6-yl)methyl acetate | HCID 22281841 | 66% |
반응 단계
1.77 g of 1 (10 mmol) in 50 ml of glacial acetic acid containing 6.5 g of MCPBA (57-85%) was refluxed for 3 hours. Acetic anhydride (40 ml) was added to the hot reaction mixture and the refluxing was continued for another half an hour. The clear brown solution was evaporated to dryness and the solid was stirred with ether (100 ml) and filtered. The solid was crystallized from ethanol to give 1.55 g (66%) of 2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05866580 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-403951847e7645e5a6556663da6b4841 |
| 출처 메모 | uspto-grants-1999_02 |