Water → 12-Methanesulfonyl-1-dodecene

HRID 361530노트

반응식

HRID 361530 반응식
[CH2:1](O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[CH2:12].[CH3:14][S:15](Cl)(=[O:17])=[O:16].C(N(CC)CC)C.O>ClCCl>[CH3:14][S:15]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[CH2:12])(=[O:17])=[O:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 52072511-Dodecen-1-ol

생성물 1

HCID 2329589712-Methanesulfonyl-1-dodecene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a solution of 11-dodecen-1-ol (5.5 g, 29.9 mmol) in dichloromethane (70 mL) at 0° C. was added methanesulfonyl chloride (3.55 g, 2.40 mL, 31.0 mmol) followed by triethylamine (4.38 g, 46.0 mmol). After stirring for 10 minutes at 0° C., the reaction was allowed to warm to 25° C. and stirred for 2 hours. The reaction was poured into water (60 mL), separated and washed with dichloromethane (50 mL). The organic portions were combined, dried using magnesium sulfate, and evaporated to yield 12-methanesulfonyl-1-dodecene as a yellow oil which was then used without further purification.

후처리

  1. temperatureto warm to 25° C.
  2. stirringstirred for 2 hours
  3. customseparated
  4. washwashed with dichloromethane (50 mL)
  5. customdried
  6. customevaporated

출처 및 근거

ORD 기록
ord-ce1e1aee86f249eda4ff206a29587a7e
출처 데이터셋
uspto-grants-1999_02
특허 번호
US05866576

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