Acetaminophen → 4'-Allyloxyacetanilide
반응식
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[CH2:12](Br)[CH:13]=[CH2:14].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:14][CH:13]=[CH2:12])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]참가 물질
5
실험 절차
Commercially available 4-acetamido phenol (1 molar equivalent), allyl bromide (1 molar equivalent) and potassium carbonate (1 molar equivalent) in butan-2-one were heated at reflux for 18 hours with stirring. The mixture was cooled, filtered and the solid residue washed with ether. The combined filtrates were evaporated and the solid residue was further purified by crystallisation from ethyl acetate-hexane to give 4-acetamido-1-allyloxy benzene as a colourless solid, m.p. 85°-86° C.
후처리
- temperatureat reflux for 18 hours
- temperatureThe mixture was cooled
- filtrationfiltered
- washthe solid residue washed with ether
- customThe combined filtrates were evaporated
- customthe solid residue was further purified by crystallisation from ethyl acetate-hexane
출처 및 근거
- ORD 기록
- ord-00d330a9d291460891b62d2b6f79ce4c
- 출처 데이터셋
- uspto-grants-1999_02
- 특허 번호
- US05866611
반응 노트
불러오는 중…