Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
U 99363 → 4-[N-Methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | U 99363 | HCID 133107 | — |
| 반응물 | Ammonium formate | HCID 2723923 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-[N-Methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine | HCID 10847368 | — |
반응 단계
A mixture of 1-benzyl-4-[N-methyl-N-(3-ethoxy-2-pyridinyl)amino]piperidine (EXAMPLE 70, 1.40 g), palladium-on-carbon (10%, 1.4 g) and ammonium formate (813 mg) in methanol (25 ml) is degassed, stirred at 65° for 45 min, cooled to 20°-25°, and filtered to remove catalyst. The filtrate is concentrated under reduced pressure to give the title compound, NMR (CDCl3) 7.83, 6.97, 6.71, 4.02, 3.88, 3.15, 2.88, 2.63, 1.75 and 1.46δ.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05866589 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-4794e628ec764be1bb45fce4998378a0 |
| 출처 메모 | uspto-grants-1999_02 |